| 别名 | FBX32 |
| 基因名称 | Endogenous |
| 蛋白名称 | FBXO32 |
| 推荐应用 | |
| 反应物种 | FBX32 |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | F-box only protein 32;Atrogin-1;Muscle atrophy F-box protein;MAFbx; |
| Human Swissprot No. | 114907 |
| Mouse Gene ID | Q969P5 |
| Mouse Swissprot No. | 67731 |
| Rat Gene ID | 171043 |
| Rat Swissprot No. | Q91Z62 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 42kD |
| 预测分子量 | WB,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 42kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011], |
| 细胞定位 | Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus. |
| 功能 | Function:Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 F-box domain.,subunit:Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXO32) formed of CUL1, SKP1A, RBX1 and FBXO32.,tissue specificity:Specifically expressed in cardiac and skeletal muscle., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG, Kappa |
| 细胞定位 | Cytoplasm . Nucleus . Shuttles between cytoplasm and the nucleus. |
| 组织表达 | Specifically expressed in cardiac and skeletal muscle. |
| 研究领域 | >>FoxO signaling pathway |
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