| 别名 | BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (Adenovirus E1B19K-binding protein B5) (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A) (NIP3-like protein X) (NIP3L) |
| 基因名称 | Endogenous |
| 蛋白名称 | BNIP3L BNIP3A BNIP3H NIX |
| 推荐应用 | |
| 反应物种 | BNI3L |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:500-1:2000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Swissprot No. | 665 |
| Mouse Gene ID | O60238 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 24kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 38kD |
| 同种型 | Rabbit |
| 背景介绍 | BCL2 interacting protein 3 like(BNIP3L) Homo sapiens This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015], |
| 细胞定位 | Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane ; Single-pass membrane protein . Colocalizes with SPATA18 at the mitochondrion outer membrane. |
| 功能 | Function:Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3.,PTM:Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.,similarity:Belongs to the NIP3 family.,subunit:Self-associates. Interacts with BNIP3 and STEAP3. Interacts with human adenovirus-2 E1B 19 kDa protein., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG, Kappa |
| 细胞定位 | Nucleus envelope. Endoplasmic reticulum. Mitochondrion outer membrane. Membrane ; Single-pass membrane protein . Colocalizes with SPATA18 at the mitochondrion outer membrane. |
| 组织表达 | Bone marrow,Brain,Cervix,Epithelium,Fetal liver,Hair follicle dermal papill |
| 研究领域 | >>Mitophagy - animal |
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