| 别名 | YTH domain family protein 2 (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) |
| 基因名称 | Endogenous |
| 蛋白名称 | YTHDF2 HGRG8 |
| 推荐应用 | |
| 反应物种 | YTHD2 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Swissprot No. | 51441 |
| Mouse Gene ID | Q9Y5A9 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 62kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 62kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene |
| 细胞定位 | Cytoplasm, Nucleus |
| 功能 | similarity:Contains 1 YTH domain., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm, Nucleus |
| 组织表达 | Highly expressed in induced pluripotent stem cells (iPSCs) and down-regulated during neural differentiation. |
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