| 别名 | TXD12 |
| 基因名称 | Endogenous |
| 蛋白名称 | TXNDC12 TLP19 UNQ713/PRO1376 |
| 推荐应用 | |
| 反应物种 | TXD12 |
| 存储缓冲液 | IHC 1:500-1:2000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Swissprot No. | 51060 |
| Mouse Gene ID | O95881 |
| Mouse Swissprot No. | 66073 |
| Rat Gene ID | 298370 |
| Rat Swissprot No. | Q498E0 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 19kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 19kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012], |
| 细胞定位 | Endoplasmic reticulum lumen . |
| 功能 | Catalytic activity:2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.,cofactor:FAD.,Function:Possesses significant protein thiol-disulfide oxidase activity.,Function:Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Extramitochondrial AIF induces nuclear chromatin condensation and large scale DNA fragmentation (in vitro). Binds to DNA in a sequence-independent manner.,similarity:Belongs to the FAD-dependent oxidoreductase family.,similarity:Contains 1 thioredoxin domain.,subcellular location:Translocated to the nucleus upon induction of apoptosis.,subunit:Interacts with XIAP.,tissue specificity:Widely expressed., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG, Kappa |
| 细胞定位 | Endoplasmic reticulum lumen . |
| 组织表达 | Widely expressed. |
| 研究领域 | >>Glutathione metabolism;>>Metabolic pathways |
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