| 别名 | Endoplasmin |
| 基因名称 | Endogenous |
| 蛋白名称 | HSP90B1 |
| 推荐应用 | |
| 反应物种 | Endoplasmin |
| 存储缓冲液 | IHC 1:1000-1:5000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | HSP90B1;GRP94;TRA1;Endoplasmin;94 kDa glucose-regulated protein;GRP-94;Heat shock protein 90 kDa beta member 1;Tumor rejection antigen 1;gp96 homolog |
| Human Swissprot No. | 7184 |
| Mouse Gene ID | P14625 |
| Mouse Swissprot No. | 22027 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 93kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 100kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012], |
| 细胞定位 | Endoplasmic reticulum |
| 功能 | Function:Molecular chaperone that functions in the processing and transport of secreted proteins. Has ATPase activity.,PTM:Phosphorylated.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Endoplasmic reticulum |
| 组织表达 | Blood,Brain,Liver,Lung,Platelet,Skin, |
| 研究领域 | >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>IL-17 signaling pathway;>>Estrogen signaling pathway;>>Thyroid hormone synthesis;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis |
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