| 别名 | RSK2 |
| 基因名称 | Endogenous |
| 蛋白名称 | RPS6KA3 ISPK1 MAPKAPK1B RSK2 |
| 推荐应用 | |
| 反应物种 | RSK2 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | Ribosomal protein S6 kinase alpha-3;S6K-alpha-3;90 kDa ribosomal protein S6 kinase 3;p90-RSK 3;p90RSK3;Insulin-stimulated protein kinase 1;ISPK-1;MAP kinase-activated protein kinase 1b;MAPK-activated protein kinase 1b;MAPKAP kinase 1b;MAPKAPK-1b;Ribosomal S6 kinase 2;RSK-2;pp90RSK2; |
| Human Swissprot No. | 6197 |
| Mouse Gene ID | P51812 |
| Mouse Swissprot No. | 110651 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 84kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 84kD |
| 同种型 | Rabbit |
| 背景介绍 | ribosomal protein S6 kinase A3(RPS6KA3) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008], |
| 细胞定位 | Nucleus . Cytoplasm . |
| 功能 | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Disease:Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-386, as part of the activation process.,PTM:Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity). Interacts with NFATC4.,tissue specificity:Expressed in many tissues, highest levels in skeletal muscle., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus . Cytoplasm . |
| 组织表达 | Expressed in many tissues, highest levels in skeletal muscle. |
| 研究领域 | >>MAPK signaling pathway;>>Oocyte meiosis;>>mTOR signaling pathway;>>Thermogenesis;>>Long-term potentiation;>>Neurotrophin signaling pathway;>>Progesterone-mediated oocyte maturation;>>Insulin resistance;>>Yersinia infection;>>Chemical carcinogenesis - receptor activation |
周一至周日 8:00-18:00
