| 别名 | Interleukin-1 beta (IL-1 beta) (Catabolin) |
| 基因名称 | Endogenous |
| 蛋白名称 | IL1B IL1F2 |
| 推荐应用 | |
| 反应物种 | IL-1β |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | IL1B;IL1F2;Interleukin-1 beta;IL-1 beta;Catabolin |
| Human Swissprot No. | 3553 |
| Mouse Gene ID | P01584 |
| Mouse Swissprot No. | 16176 |
| Rat Swissprot No. | Q63264 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 31kD |
| 预测分子量 | WB,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | pro:31kD,mature:17kD |
| 同种型 | Rabbit |
| 背景介绍 | interleukin 1 beta(IL1B) Homo sapiens The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Secreted |
| 功能 | Domain:The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.,Function:Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.,online information:Interleukin-1 entry,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the IL-1 family.,subcellular location:The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.,subunit:Monomer., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Secreted |
| 组织表达 | Expressed in activated monocytes/macrophages (at protein level). |
| 研究领域 | >>Antifolate resistance;>>MAPK signaling pathway;>>Cytokine-cytokine receptor interaction;>>NF-kappa B signaling pathway;>>Necroptosis;>>Osteoclast differentiation;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>Cytosolic DNA-sensing pathway;>>C-type lectin receptor signaling pathway;>>Hematopoietic cell lineage;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>TNF signaling pathway;>>Inflammatory mediator regulation of TRP channels;>>Non-alcoholic fatty liver disease;>>AGE-RAGE signaling pathway in diabetic complications;>>Alcoholic liver disease;>>Type I diabetes mellitus;>>Alzheimer disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Legionellosis;>>Yersinia infection;>>Leishmaniasis;>>Chagas disease;>>African trypanosomiasis;>>Malaria;>>Amoebiasis;>>Tuberculosis;>>Measles;>>Human cytomegalovirus infection;>>Influenza A;>>Herpes simplex virus 1 infection;>>Coronavirus disease - COVID-19;>>Inflammatory bowel disease;>>Rheumatoid arthritis;>>Graft-versus-host disease;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis |
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