| 别名 | CCAAT/enhancer-binding protein alpha |
| 基因名称 | Endogenous |
| 蛋白名称 | CEBPA |
| 推荐应用 | |
| 反应物种 | C/EBP α |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | CEBPA;CCAAT/enhancer-binding protein alpha;C/EBP alpha |
| Human Swissprot No. | 1050 |
| Mouse Gene ID | P49715 |
| Mouse Swissprot No. | 12606 |
| Rat Gene ID | 24252 |
| Rat Swissprot No. | P05554 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 38kD |
| 预测分子量 | WB,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 43kD |
| 同种型 | Rabbit |
| 背景介绍 | This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013], |
| 细胞定位 | Nucleus |
| 功能 | Function:C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. C/EBP subfamily.,similarity:Contains 1 bZIP domain.,subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP beta and gamma. Interacts with UBN1. Interacts with HBV protein X., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus |
| 组织表达 | Liver,Pancreas,Umbilical cord,White Matter pool- 5 brain tissues- f |
| 研究领域 | >>Non-alcoholic fatty liver disease;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia |
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