| 别名 | Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17) |
| 基因名称 | Endogenous |
| 蛋白名称 | CLTC CLH17 CLTCL2 KIAA0034 |
| 推荐应用 | |
| 反应物种 | Clathrin Heavy Chain 1 |
| 存储缓冲液 | IHC 1:50-200;WB 1:500-1:2000;IF 1:200-1000;ELISA 1:5000-20000 |
| Human Swissprot No. | 1213 |
| Mouse Gene ID | Q00610 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 192kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 180kD |
| 同种型 | Rabbit |
| 背景介绍 | Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm |
| 功能 | Function:Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.,online information:Clathrin entry,similarity:Belongs to the clathrin heavy chain family.,subcellular location:Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium. Interacts with HIP1., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm |
| 组织表达 | Bone marrow,Brain,Cervix carcinoma,Colon,Epithelium,Fetal kidney,Hepatoma,Mammary c |
| 研究领域 | >>Lysosome;>>Endocytosis;>>Synaptic vesicle cycle;>>Endocrine and other factor-regulated calcium reabsorption;>>Huntington disease;>>Bacterial invasion of epithelial cells |
周一至周日 8:00-18:00
