| 别名 | Mixed lineage kinase domain-like protein |
| 基因名称 | Endogenous |
| 蛋白名称 | MLKL |
| 推荐应用 | |
| 反应物种 | MLKL |
| 存储缓冲液 | IHC 1:1000-1:4000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | MLKL;Mixed lineage kinase domain-like protein |
| Human Swissprot No. | 197259 |
| Mouse Gene ID | Q8NB16 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 55kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 55kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015], |
| 细胞定位 | Cytoplasm |
| 功能 | Domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm |
| 组织表达 | Chondrocyte,Leukocyte,Lymph node, |
| 研究领域 | >>Necroptosis;>>TNF signaling pathway;>>Salmonella infection |
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