| 别名 | Signal transducer and activator of transcription 6 |
| 基因名称 | Endogenous |
| 蛋白名称 | STAT6 |
| 推荐应用 | |
| 反应物种 | Stat6 |
| 存储缓冲液 | IHC 1:500-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | STAT6;Signal transducer and activator of transcription 6;IL-4 Stat |
| Human Swissprot No. | 6778 |
| Mouse Gene ID | P42226 |
| Mouse Swissprot No. | 20852 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 94kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 110kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010], |
| 细胞定位 | Nucleus |
| 功能 | Function:Carries out a dual Function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.,PTM:Tyrosine phosphorylated following stimulation by IL-4 and IL-3.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus in response to phosphorylation.,subunit:Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus |
| 组织表达 | Uterus, |
| 研究领域 | >>Necroptosis;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Hepatitis B;>>Pathways in cancer;>>Inflammatory bowel disease |
周一至周日 8:00-18:00
