| 别名 | Bcl-2-binding component 3 |
| 基因名称 | Endogenous |
| 蛋白名称 | BBC3 |
| 推荐应用 | |
| 反应物种 | PUMA |
| 存储缓冲液 | IHC 1:500-1:2000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | BBC3;PUMA;Bcl-2-binding component 3;JFY-1;p53 up-regulated modulator of apoptosis |
| Human Swissprot No. | 27113 |
| Mouse Gene ID | Q9BXH1 |
| Mouse Swissprot No. | 170770 |
| Rat Gene ID | 317673 |
| Rat Swissprot No. | Q80ZG6 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 21kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 21kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011], |
| 细胞定位 | Mitochondrion |
| 功能 | Function:Essential mediator of p53-dependent and p53-independent apoptosis.,induction:By DNA damage, glucocorticoid treatment, growth factor deprivation and p53.,similarity:Belongs to the Bcl-2 family.,subcellular location:Localized to the mitochondria in order to induce cytochrome c release.,subunit:Interacts with MCL1 and BCL2A1 (By similarity). Interacts with BCL2 and BCL2L1/BCL-XL.,tissue specificity:Ubiquitously expressed., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Mitochondrion |
| 组织表达 | Ubiquitously expressed. |
| 研究领域 | >>Platinum drug resistance;>>p53 signaling pathway;>>Apoptosis;>>Apoptosis - multiple species;>>Hippo signaling pathway;>>Huntington disease;>>Measles;>>Pathways in cancer;>>Colorectal cancer |
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