| 别名 | Bcl-2-like protein 11 |
| 基因名称 | Endogenous |
| 蛋白名称 | BCL2L11 |
| 推荐应用 | |
| 反应物种 | Bim |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | BCL2L11;BIM;Bcl-2-like protein 11;Bcl2-L-11;Bcl2-interacting mediator of cell death |
| Human Swissprot No. | 10018 |
| Mouse Gene ID | O43521 |
| Mouse Swissprot No. | 12125 |
| Rat Gene ID | 64547 |
| Rat Swissprot No. | O88498 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 22kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 22kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013], |
| 细胞定位 | Endomembrane |
| 功能 | Domain:The BH3 motif is required for Bcl-2 binding and cytotoxicity.,Function:Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.,similarity:Belongs to the Bcl-2 family.,subcellular location:Associated with intracytoplasmic membranes.,subunit:Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK.,tissue specificity:Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Endomembrane |
| 组织表达 | Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are widely expressed with tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. |
| 研究领域 | >>EGFR tyrosine kinase inhibitor resistance;>>FoxO signaling pathway;>>PI3K-Akt signaling pathway;>>Apoptosis;>>Apoptosis - multiple species;>>Non-alcoholic fatty liver disease;>>Epstein-Barr virus infection;>>Pathways in cancer;>>MicroRNAs in cancer;>>Colorectal cancer |
周一至周日 8:00-18:00
