| 别名 | Elongation factor 2 |
| 基因名称 | Endogenous |
| 蛋白名称 | EEF2 |
| 推荐应用 | |
| 反应物种 | eEF2 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | EEF2;EF2;Elongation factor 2;EF-2 |
| Human Swissprot No. | 1938 |
| Mouse Gene ID | P13639 |
| Mouse Swissprot No. | 13629 |
| Rat Gene ID | 29565 |
| Rat Swissprot No. | P05197 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 95kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 95kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm . Nucleus . Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. . |
| 功能 | Function:This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome.,PTM:Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A.,PTM:Phosphorylation by EF-2 kinase completely inactivates EF-2.,similarity:Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.,subunit:Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm . Nucleus . Phosphorylation by CSK promotes cleavage and SUMOylation-dependent nuclear translocation of the C-terminal cleavage product. . |
| 组织表达 | Brain,Cajal-Retzius cell,Epithelium,Hepatocyte,Ovary,Periph |
| 研究领域 | >>AMPK signaling pathway;>>Oxytocin signaling pathway |
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