| 别名 | Transcription factor A mitochondrial |
| 基因名称 | Endogenous |
| 蛋白名称 | TFAM |
| 推荐应用 | |
| 反应物种 | mtTFA |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | TFAM;TCF6;TCF6L2;Transcription factor A;mitochondrial;mtTFA;Mitochondrial transcription factor 1;MtTF1;Transcription factor 6;TCF-6;Transcription factor 6-like 2 |
| Human Swissprot No. | 7019 |
| Mouse Gene ID | Q00059 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 29kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 24kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012], |
| 细胞定位 | Mitochondrion |
| 功能 | Function:Involved in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA.,similarity:Contains 2 HMG box DNA-binding domains.,subunit:Interacts with TFB1M and TFB2M., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Mitochondrion |
| 组织表达 | Lymphocyte,Pooled,Uterus, |
| 研究领域 | >>Apelin signaling pathway;>>Huntington disease |
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