| 别名 | Glutamate--cysteine ligase regulatory subunit |
| 基因名称 | Endogenous |
| 蛋白名称 | GCLM |
| 推荐应用 | |
| 反应物种 | GCLM |
| 存储缓冲液 | IHC 1:200-1:500;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200, |
| Human Gene Link | GCLM;GLCLR;Glutamate--cysteine ligase regulatory subunit;GCS light chain;Gamma-ECS regulatory subunit;Gamma-glutamylcysteine synthetase regulatory subunit;Glutamate--cysteine ligase modifier subunit |
| Human Swissprot No. | 2730 |
| Mouse Gene ID | P48507 |
| Mouse Swissprot No. | 14630 |
| Rat Gene ID | 29739 |
| Rat Swissprot No. | P48508 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 31kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 31kD |
| 同种型 | Rabbit |
| 背景介绍 | Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015], |
| 细胞定位 | Cytoplasm |
| 功能 | pathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.,similarity:Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.,subunit:Heterodimer of a catalytic heavy chain and a regulatory light chain.,tissue specificity:In all tissues examined. Highest levels in skeletal muscle., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm |
| 组织表达 | In all tissues examined. Highest levels in skeletal muscle. |
| 研究领域 | >>Cysteine and methionine metabolism;>>Glutathione metabolism;>>Metabolic pathways;>>Biosynthesis of cofactors;>>Ferroptosis |
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