| 别名 | Macrophage mannose receptor 1 |
| 基因名称 | Endogenous |
| 蛋白名称 | MRC1 |
| 推荐应用 | |
| 反应物种 | CD206 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:5000-1:20000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | MRC1;CLEC13D;CLEC13DL;MRC1L1;Macrophage mannose receptor 1;MMR;C-type lectin domain family 13 member D;C-type lectin domain family 13 member D-like;Macrophage mannose receptor 1-like protein 1;CD206 |
| Human Swissprot No. | 4360 |
| Mouse Gene ID | P22897 |
| Mouse Swissprot No. | 17533 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 166kDa |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 190kD |
| 同种型 | Rabbit |
| 背景介绍 | The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015], |
| 细胞定位 | Membrane |
| 功能 | Function:Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.,miscellaneous:CRDs 1-3 have at most very weak affinity for carbohydrate. CRD 4 shows the highest affinity binding and has multispecificity for a variety of monosaccharides. At least 3 CRDs (4, 5, and 7) are required for high affinity binding and endocytosis of multivalent glycoconjugates.,online information:Macrophage mannose receptor,similarity:Contains 1 fibronectin type-II domain.,similarity:Contains 1 ricin B-type lectin domain.,similarity:Contains 8 C-type lectin domains., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Membrane |
| 组织表达 | Milk,Placenta,Testis, |
| 研究领域 | >>Phagosome;>>Tuberculosis |
周一至周日 8:00-18:00
