| 别名 | Beclin-1 |
| 基因名称 | Endogenous |
| 蛋白名称 | BECN1 GT197 |
| 推荐应用 | |
| 反应物种 | Beclin 1 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) |
| Human Swissprot No. | 8678 |
| Mouse Gene ID | Q14457 |
| Mouse Swissprot No. | 56208 |
| Rat Gene ID | 114558 |
| Rat Swissprot No. | Q91XJ1 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 52kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 60kD |
| 同种型 | Rabbit |
| 背景介绍 | beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015], |
| 细胞定位 | Cytoplasm |
| 功能 | Function:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm |
| 组织表达 | Ubiquitous. |
| 研究领域 | >>Autophagy - other;>>Mitophagy - animal;>>Autophagy - animal;>>Apoptosis - multiple species;>>Apelin signaling pathway;>>Alzheimer disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Spinocerebellar ataxia;>>Pathways of neurodegeneration - multiple diseases;>>Shigellosis;>>Kaposi sarcoma-associated herpesvirus infection |
周一至周日 8:00-18:00
