| 别名 | Perilipin-1 (Lipid droplet-associated protein) |
| 基因名称 | Endogenous |
| 蛋白名称 | PLIN1 PERI PLIN |
| 推荐应用 | |
| 反应物种 | PLIN1 |
| 存储缓冲液 | IHC 1:400-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Swissprot No. | 5346 |
| Mouse Gene ID | O60240 |
| Mouse Swissprot No. | 103968 |
| Rat Gene ID | 25629 |
| Rat Swissprot No. | P43884 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 56kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 56kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009] |
| 细胞定位 | Endoplasmic reticulum |
| 功能 | Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Endoplasmic reticulum |
| 组织表达 | Detected in adipocytes from white adipose tissue (at protein level) (PubMed:27832861). Detected in visceral adipose tissue and mammary gland (PubMed:9521880). |
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