| 别名 | Paxillin |
| 基因名称 | This antibody detects endogenous levels of Paxillin only when phosphorylated at Tyr118.This antibody does not recognize phosphorylated at other sites. |
| 蛋白名称 | PXN |
| 推荐应用 | |
| 反应物种 | Paxillin |
| 存储缓冲液 | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | PXN;Paxillin |
| Human Swissprot No. | 5829 |
| Mouse Gene ID | P49023 |
| Mouse Swissprot No. | 19303 |
| Rat Gene ID | 360820 |
| Rat Swissprot No. | Q66H76 |
| 特异性 | Monoclonal |
| 稀释度 | Phospho |
| 参考分子量 | 65kD |
| 预测分子量 | WB,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 65kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011], |
| 细胞定位 | Cytoplasm, Nucleus |
| 功能 | Function:Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).,PTM:Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens.,similarity:Belongs to the paxillin family.,similarity:Contains 3 LIM zinc-binding domains.,similarity:Contains 4 LIM zinc-binding domains.,subunit:Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the SH2 domain of V-CRK. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1 (By similarity). Binds ASAP2. Interacts with unphosphorylated ITGA4. Interacts with RNF5., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm, Nucleus |
| 组织表达 | Brain,Epithelium,Lung,Placenta,T-cell,Uterus, |
| 研究领域 | >>Chemokine signaling pathway;>>VEGF signaling pathway;>>Focal adhesion;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Bacterial invasion of epithelial cells;>>Shigellosis;>>Yersinia infection;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Human immunodeficiency virus 1 infection;>>Viral carcinogenesis;>>Proteoglycans in cancer |
周一至周日 8:00-18:00
