| 别名 | RNA-binding protein Musashi homolog 1 |
| 基因名称 | Endogenous |
| 蛋白名称 | MSI1 |
| 推荐应用 | |
| 反应物种 | Msi1 |
| 存储缓冲液 | IHC 1:100-1:400;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200; |
| Human Gene Link | MSI1;RNA-binding protein Musashi homolog 1;Musashi-1 |
| Human Swissprot No. | 4440 |
| Mouse Gene ID | O43347 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 39kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 39kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm . Nucleus . |
| 功能 | Domain:The first RNA recognition motif binds more strongly to RNA compared to the second one.,Function:RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.,similarity:Belongs to the Musashi family.,similarity:Contains 2 RRM (RNA recognition motif) domains.,tissue specificity:Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm . Nucleus . |
| 组织表达 | Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines. |
| 研究领域 | >>mRNA surveillance pathway |
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