| 别名 | Ferritin heavy chain |
| 基因名称 | Endogenous |
| 蛋白名称 | FTH1 |
| 推荐应用 | |
| 反应物种 | Ferritin heavy chain |
| 存储缓冲液 | IHC 1:2000-1:10000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | FTH1;FTH;FTHL6;OK/SW-cl.84;PIG15;Ferritin heavy chain;Ferritin H subunit;Cell proliferation-inducing gene 15 protein |
| Human Swissprot No. | 2495 |
| Mouse Gene ID | P02794 |
| Mouse Swissprot No. | 14319 |
| Rat Gene ID | 25319 |
| Rat Swissprot No. | P19132 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 21kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 21kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm |
| 功能 | Catalytic activity:4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.,Function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis.,Function:Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.,miscellaneous:In human liver the heavy chain is the major chain.,online information:Ferritin entry,similarity:Belongs to the ferritin family.,similarity:Contains 1 ferritin-like diiron domain.,subunit:Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm |
| 组织表达 | Expressed in the liver. |
| 研究领域 | >>Ferroptosis;>>Necroptosis;>>Mineral absorption |
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