| 别名 | Prostaglandin G/H synthase 2 (Cyclooxygenase-2) (COX-2) (PHS II) (Prostaglandin H2 synthase 2) (PGH synthase 2) (PGHS-2) (Prostaglandin-endoperoxide synthase 2) |
| 基因名称 | Endogenous |
| 蛋白名称 | PTGS2 COX2 |
| 推荐应用 | |
| 反应物种 | COX2 |
| 存储缓冲液 | IHC 1:100-1:500;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000, |
| Human Swissprot No. | 5743 |
| Mouse Gene ID | P35354 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 69kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 75kD |
| 同种型 | Rabbit |
| 背景介绍 | Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009], |
| 细胞定位 | Cytoplasm |
| 功能 | Catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,Disease:Likely to play a role in inflammatory diseases such as rheumatoid arthritis.,Function:May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.,induction:By cytokines and mitogens.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm |
| 组织表达 | Endothelial cell,Epidermal keratinocytes in primary culture,Lung,Pe |
| 研究领域 | >>Arachidonic acid metabolism;>>Metabolic pathways;>>NF-kappa B signaling pathway;>>VEGF signaling pathway;>>C-type lectin receptor signaling pathway;>>IL-17 signaling pathway;>>TNF signaling pathway;>>Retrograde endocannabinoid signaling;>>Serotonergic synapse;>>Ovarian steroidogenesis;>>Oxytocin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Leishmaniasis;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Pathways in cancer;>>Chemical carcinogenesis - DNA adducts;>>MicroRNAs in cancer;>>Small cell lung cancer |
周一至周日 8:00-18:00
