| 别名 | Stromelysin-1 |
| 基因名称 | Endogenous |
| 蛋白名称 | MMP3 |
| 推荐应用 | |
| 反应物种 | MMP-3 |
| 存储缓冲液 | IHC 1:200-1:1000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Human Gene Link | MMP3;STMY1;Stromelysin-1;SL-1;Matrix metalloproteinase-3;MMP-3;Transin-1 |
| Human Swissprot No. | 4314 |
| Mouse Gene ID | P08254 |
| Mouse Swissprot No. | 17392 |
| Rat Swissprot No. | P03957 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 54kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 54kD |
| 同种型 | Rabbit |
| 背景介绍 | matrix metallopeptidase 3(MMP3) Homo sapiens Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm |
| 功能 | Catalytic activity:Preferential cleavage where P1', P2' and P3' are hydrophobic residues.,cofactor:Binds 2 zinc ions per subunit.,cofactor:Binds 4 calcium ions per subunit.,Domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,Function:Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm |
| 组织表达 | Fibroblast,Lung,Synovium, |
| 研究领域 | >>IL-17 signaling pathway;>>TNF signaling pathway;>>Coronavirus disease - COVID-19;>>Transcriptional misregulation in cancer;>>Prostate cancer;>>Rheumatoid arthritis;>>Lipid and atherosclerosis |
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