| 别名 | Heat shock 70 kDa protein 1A/1B |
| 基因名称 | Endogenous |
| 蛋白名称 | HSPA1A;HSPA1B |
| 推荐应用 | |
| 反应物种 | HSP70 |
| 存储缓冲液 | IHC 1:400-1000;WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000; |
| Human Gene Link | HSPA1A;HSPA1;HSPA1B;Heat shock 70 kDa protein 1A/1B;Heat shock 70 kDa protein 1/2;HSP70-1/HSP70-2;HSP70.1/HSP70.2 |
| Human Swissprot No. | 3303;3304 |
| Mouse Gene ID | P0DMV8;P0DMV9; |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 70kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 70kD |
| 同种型 | Rabbit |
| 背景介绍 | This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Nucleus |
| 功能 | Function:In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.,induction:By heat shock.,similarity:Belongs to the heat shock protein 70 family.,subunit:HSPA1B is found in a sperm-specific complex with CATSPER1 and CATSPERB (By similarity). Interacts with TSC2. Interacts with IRAK1BP1.,tissue specificity:HSPA1B is testis-specific., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus |
| 组织表达 | Brain,Cajal-Retzius cell,Embryonic kidney,Epithelium,Fetal |
| 研究领域 | >>Spliceosome;>>MAPK signaling pathway;>>Protein processing in endoplasmic reticulum;>>Endocytosis;>>Longevity regulating pathway - multiple species;>>Antigen processing and presentation;>>Estrogen signaling pathway;>>Prion disease;>>Legionellosis;>>Toxoplasmosis;>>Measles;>>Lipid and atherosclerosis |
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