| 别名 | Prohibitin |
| 基因名称 | Endogenous |
| 蛋白名称 | PHB |
| 推荐应用 | |
| 反应物种 | Prohibitin |
| 存储缓冲液 | IHC 1:200-1000;WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200 |
| Human Gene Link | PHB;Prohibitin |
| Human Swissprot No. | 5245 |
| Mouse Gene ID | P35232 |
| Mouse Swissprot No. | 18673 |
| Rat Gene ID | 25344 |
| Rat Swissprot No. | P67779 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 30kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 30kD |
| 同种型 | Rabbit |
| 背景介绍 | prohibitin(PHB) Homo sapiens This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013], |
| 细胞定位 | Cytoplasm |
| 功能 | developmental stage:Levels of expression in fibroblasts decrease heterogeneously during cellular aging.,Disease:Mutated in sporadic breast cancer.,Function:Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.,induction:Expression increases approximately 3-fold upon entry into G1 phase compared with other phases of the cell cycle. Also induced following inhibition of mitochondrial protein synthesis by thiamphenicol.,similarity:Belongs to the prohibitin family.,subunit:Interacts with PHB2.,tissue specificity:Widely expressed in different tissues., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm |
| 组织表达 | Widely expressed in different tissues. |
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