| 别名 | Excitatory amino acid transporter 1 |
| 基因名称 | Endogenous |
| 蛋白名称 | SLC1A3 |
| 推荐应用 | |
| 反应物种 | EAAT1 |
| 存储缓冲液 | IHC 1:200-1000;WB 1:500-2000;IF 1:200-1000;ELISA 1:5000-20000; |
| Human Gene Link | SLC1A3;EAAT1;GLAST;GLAST1;Excitatory amino acid transporter 1;Sodium-dependent glutamate/aspartate transporter 1;GLAST-1;Solute carrier family 1 member 3 |
| Human Swissprot No. | 6507 |
| Mouse Gene ID | P43003 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 60kD |
| 预测分子量 | WB,IHC,IF,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 59kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014], |
| 细胞定位 | Cell membrane |
| 功能 | Disease:Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6) [MIM:612656]. EA6 is characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.,Function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.,PTM:Glycosylated.,similarity:Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family.,tissue specificity:Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cell membrane |
| 组织表达 | Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008). Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911). |
| 研究领域 | >>Synaptic vesicle cycle;>>Glutamatergic synapse;>>Huntington disease |
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