| 别名 | PPARGC1B PERC PGC1 PGC1B PPARGC1 |
| 基因名称 | Endogenous |
| 蛋白名称 | PPARGC1B |
| 推荐应用 | |
| 反应物种 | PGC1 β |
| 存储缓冲液 | WB 1:1000-1:5000;ELISA 1:5000-1:20000;IP 1:50-1:200, |
| Human Swissprot No. | 133522 |
| Mouse Gene ID | Q86YN6 |
| Mouse Swissprot No. | 170826 |
| Rat Gene ID | 291567 |
| Rat Swissprot No. | Q811R2 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 113kD |
| 预测分子量 | WB,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 113kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene stimulates the activity of several transcription factors and nuclear receptors, including estrogen receptor alpha, nuclear respiratory factor 1, and glucocorticoid receptor. The encoded protein may be involved in fat oxidation, non-oxidative glucose metabolism, and the regulation of energy expenditure. This protein is downregulated in prediabetic and type 2 diabetes mellitus patients. Certain allelic variations in this gene increase the risk of the development of obesity. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010], |
| 细胞定位 | Nucleus |
| 功能 | Domain:Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motif, which are usually required for the association with nuclear receptors.,Function:Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure.,induction:Repressed by saturated fatty acids such as palmitate and stearate in skeletal muscle cells. Induced by insulin and reduced by aging in skeletal muscle biopsies. Down-regulated in type 2 diabetes mellitus subjects as well as in pre-diabetics.,polymorphism:Variation of PPARGC1B may contribute to the pathogenesis of obesity, with a widespread Ala-203 allele being a risk factor for the development of this common disorders.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with hepatocyte nuclear factor 4-alpha/HNF4A, Sterol regulatory binding transcription factor 1/SREBF1, PPAR-alpha/PPARA, thyroid hormone receptor beta/THRB and host cell factor/HCFC1. Interacts with estrogen-related receptor gamma/ESRRG and alpha/ESRRA (By similarity). Interacts with estrogen receptor alpha/ESR1.,tissue specificity:Ubiquitous with higher expression in heart, brain and skeletal muscle., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nucleus |
| 组织表达 | Ubiquitous with higher expression in heart, brain and skeletal muscle. |
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