| 别名 | GLSK |
| 基因名称 | Endogenous |
| 蛋白名称 | GLS GLS1 KIAA0838 |
| 推荐应用 | |
| 反应物种 | GLSK |
| 存储缓冲液 | IHC 1:200-1000;WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200 |
| Human Swissprot No. | 2744 |
| Mouse Gene ID | O94925 |
| Mouse Swissprot No. | 14660 |
| Rat Gene ID | 24398 |
| Rat Swissprot No. | P13264 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 68kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 55-65kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes the K-type mitochondrial glutaminase. The encoded protein is an phosphate-activated amidohydrolase that catalyzes the hydrolysis of glutamine to glutamate and ammonia. This protein is primarily expressed in the brain and kidney plays an essential role in generating energy for metabolism, synthesizing the brain neurotransmitter glutamate and maintaining acid-base balance in the kidney. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012], |
| 细胞定位 | Cytoplasm |
| 功能 | Catalytic activity:L-glutamine + H(2)O = L-glutamate + NH(3).,Function:Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine.,similarity:Belongs to the glutaminase family.,similarity:Contains 1 ANK repeat.,tissue specificity:KGA is expressed predominantly in brain and kidney but not in liver, GAC is expressed principally in cardiac muscle and pancreas but not in liver or brain, and GAM is expressed solely in cardiac and skeletal muscle., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm |
| 组织表达 | Isoform 1 and isoform 3 are detected in brain cortex. Isoform 3 is highly expressed in astrocytoma, ganglioglioma and ependymoma. Isoform 1 is highly expressed in brain and kidney, but not detected in liver. Isoform 3 is highly expressed in heart and pancreas, detected at lower levels in placenta, lung, pancreas and kidney, but is not detected in liver. Isoform 2 is expressed in cardiac and skeletal muscle. |
| 研究领域 | >>Arginine biosynthesis;>>Alanine, aspartate and glutamate metabolism;>>D-Amino acid metabolism;>>Metabolic pathways;>>Glutamatergic synapse;>>GABAergic synapse;>>Proximal tubule bicarbonate reclamation;>>MicroRNAs in cancer;>>Central carbon metabolism in cancer |
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