| 别名 | Transcription factor Sp1 |
| 基因名称 | Endogenous |
| 蛋白名称 | SP1 |
| 推荐应用 | |
| 反应物种 | Sp1 |
| 存储缓冲液 | IHC 1:200-1000;WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200 |
| Human Gene Link | SP1;TSFP1;Transcription factor Sp1 |
| Human Swissprot No. | 6667 |
| Mouse Gene ID | P08047 |
| Mouse Swissprot No. | 20683 |
| Rat Gene ID | 24790 |
| Rat Swissprot No. | Q01714 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 81kDa |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 100kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014], |
| 细胞定位 | Nuclear |
| 功能 | Function:Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter.,PTM:O-glycosylated; contains N-acetylglucosamine side chains.,similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interacts with ATF7IP, ATF7IP2, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein and HIV-1 Vpr. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the two proteins in DNA binding., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Nuclear |
| 组织表达 | Up-regulated in adenocarcinomas of the stomach (at protein level). Isoform 3 is ubiquitously expressed at low levels. |
| 研究领域 | >>Endocrine resistance;>>Mitophagy - animal;>>TGF-beta signaling pathway;>>Estrogen signaling pathway;>>Cortisol synthesis and secretion;>>Parathyroid hormone synthesis, secretion and action;>>Cushing syndrome;>>Huntington disease;>>Spinocerebellar ataxia;>>Human cytomegalovirus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Breast cancer;>>Choline metabolism in cancer;>>Diabetic cardiomyopathy |
周一至周日 8:00-18:00
