| 别名 | Intercellular adhesion molecule 1 |
| 基因名称 | Endogenous |
| 蛋白名称 | ICAM1 |
| 推荐应用 | |
| 反应物种 | CD54 |
| 存储缓冲液 | IHC 1:100-200;WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200 |
| Human Gene Link | ICAM1;Intercellular adhesion molecule 1;ICAM-1;Major group rhinovirus receptor;CD antigen CD54 |
| Human Swissprot No. | 3383 |
| Mouse Gene ID | P05362 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 58kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 100kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Membranous |
| 功能 | Function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Membranous |
| 组织表达 | Blood,Kidney,Liver,Melanoma,Plasma, |
| 研究领域 | >>NF-kappa B signaling pathway;>>Cell adhesion molecules;>>Natural killer cell mediated cytotoxicity;>>TNF signaling pathway;>>Leukocyte transendothelial migration;>>AGE-RAGE signaling pathway in diabetic complications;>>African trypanosomiasis;>>Malaria;>>Staphylococcus aureus infection;>>Influenza A;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Rheumatoid arthritis;>>Viral myocarditis;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis |
周一至周日 8:00-18:00
