| 别名 | G2/mitotic-specific cyclin-B1 |
| 基因名称 | This antibody detects endogenous levels of Cyclin B1 only when phosphorylated at Ser126.This antibody does not recognize phosphorylated at other sites. |
| 蛋白名称 | CCNB1 CCNB |
| 推荐应用 | |
| 反应物种 | Cyclin B1 |
| 存储缓冲液 | IHC 1:500-1:2000;WB 1:1000-1:5000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200, |
| Human Gene Link | CCNB1;CCNB;G2/mitotic-specific cyclin-B1 |
| Human Swissprot No. | 891 |
| Mouse Gene ID | P14635 |
| Mouse Swissprot No. | 268697 |
| Rat Gene ID | 25203 |
| Rat Swissprot No. | P30277 |
| 特异性 | Monoclonal |
| 稀释度 | Phospho |
| 参考分子量 | 48kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 55kD |
| 同种型 | Rabbit |
| 背景介绍 | The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008], |
| 细胞定位 | Cytoplasm, Nuclear |
| 功能 | developmental stage:Accumulates steadily during G2 and is abruptly destroyed at mitosis.,Function:Essential for the control of the cell cycle at the G2/M (mitosis) transition.,PTM:Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin AB subfamily.,subunit:Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm, Nuclear |
| 组织表达 | Breast adenocarcinoma,Lung,Placenta, |
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