| 别名 | Heat shock protein HSP 90-beta |
| 基因名称 | Endogenous |
| 蛋白名称 | HSP90AB1 |
| 推荐应用 | |
| 反应物种 | Hsp90β |
| 存储缓冲液 | IHC 1:200-1000;WB 1:1000-5000;IF 1:200-1000;ELISA 1:5000-20000;IP 1:50-200 |
| Human Gene Link | HSP90AB1;HSP90B;HSPC2;HSPCB;Heat shock protein HSP 90-beta;HSP 90;Heat shock 84 kDa;HSP 84;HSP84 |
| Human Swissprot No. | 3326 |
| Mouse Gene ID | P08238 |
| Mouse Swissprot No. | 15516 |
| Rat Gene ID | 301252 |
| Rat Swissprot No. | P34058 |
| 特异性 | Monoclonal |
| 稀释度 | Unmodified |
| 参考分子量 | 85kD |
| 预测分子量 | WB,IHC,IF,IP,ELISA |
| 运输及保存条件 | Protein A |
| 宿主 | 85kD |
| 同种型 | Rabbit |
| 背景介绍 | This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012], |
| 细胞定位 | Cytoplasm, Nuclear |
| 功能 | Function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer., |
| 纯化 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Clonality | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 修饰类型 | IgG,Kappa |
| 细胞定位 | Cytoplasm, Nuclear |
| 组织表达 | Amygdala,Brain cortex,Colon,Colon carcinoma,Embryon |
| 研究领域 | >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis |
周一至周日 8:00-18:00
