货号：BSCY6008
CD271, TNFRSF16, NGFR, Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, Low-affinity nerve growth factor receptor p75NGFR, Low-affinity nerve growth factor receptor p75NGR, p75 ICD, NGF receptor
| 别名 | CD271, TNFRSF16, NGFR, Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, Low-affinity nerve growth factor receptor p75NGFR, Low-affinity nerve growth factor receptor p75NGR, p75 ICD, NGF receptor |
| 基因名称 | NGFR |
| 蛋白名称 | Tumor necrosis factor receptor superfamily member 16 |
| 推荐应用 | |
| 反应物种 | Human,Rat（WB);Human Mouse Rat（IHC) |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500-1:2000;IHC-P 1:50-1:200 |
| 参考分子量 | MW(Observed):75kD |
| 预测分子量 | MW(Calculated):45kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region , a single transmembrane domain , and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. |
| 细胞定位 | Cell membrane ; Single-pass type I membrane protein . |
| 功能 | Domain:Death domain is responsible for interaction with RANBP9. ,Domain:The extracellular domain is responsible for interaction with NTRK1. ,Function:Low affinity receptor which can bind to NGF , BDNF , NT-3 , and NT-4. Can mediate cell survival as well as cell death of neural cells. ,PTM:N- and O-glycosylated. ,PTM:O-linked glycans consist of Gal (1-3) GalNAc core elongated by 1 or 2 NeuNAc. ,PTM:Phosphorylated on serine residues. ,similarity:Contains 1 death domain. ,similarity:Contains 4 TNFR-Cys repeats. ,subunit:Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2 , TRAF4 , TRAF6 , PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. Interacts with KIDINS220 and NTRK1. Can form a ternary complex with NTRK1 and KIDINS220 and this complex is affected by the expression levels of KIDINS220. An increase in KIDINS220 expression leads to a decreased association of NGFR and NTRK1 (By similarity) . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane ; Single-pass type I membrane protein . |
| 组织表达 | Brain, Spinal cord, Skin, Neuroblastoma, Melanoma, Schwannoma |
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