| 别名 | BAK, BCL2L7, CDN1, BAK1, Bcl-2 homologous antagonist/killer, Apoptosis regulator BAK, Bcl-2-like protein 7, Bcl2-L-7 |
| 基因名称 | BAK1 |
| 蛋白名称 | Bcl-2 homologous antagonist/killer |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500-1:2000;IHC-P 1:50-1:200 |
| 参考分子量 | MW(Observed):23kD |
| 预测分子量 | MW(Calculated):23kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria , and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel , which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress. |
| 细胞定位 | Mitochondrion outer membrane |
| 功能 | Caution:Could be the product of a pseudogene. ,domain:Intact BH3 domain is required by BIK , BID , BAK , BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. Apoptotic members of the Bcl-2 family. ,domain:Intact BH3 motif is required by BIK , BID , BAK , BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. ,Function:In the presence of an appropriate stimulus , accelerates programmed cell death by binding to , and antagonizing the a repressor Bcl-2 or its adenovirus homolog E1B 19k protein. ,Function:In the presence of an appropriate stimulus , accelerates programmed cell death by binding to , and antagonizing the a. repressor BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. ,similarity:Belongs to the Bcl-2 family. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Mitochondrion outer membrane |
| 组织表达 | Ubiquitous expression |
周一至周日 8:00-18:00
