| 别名 | EAAT1, GLAST, GLAST1, SLC1A3, Excitatory amino acid transporter 1, Sodium-dependent glutamate/aspartate transporter 1, Solute carrier family 1 member 3, GLAST-1 |
| 基因名称 | SLC1A3 |
| 蛋白名称 | Excitatory amino acid transporter 1 |
| 推荐应用 | |
| 反应物种 | Mouse,Rat（WB);Human Mouse Rat（IHC) |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500-1:2000;IHC-P 1:50-1:200 |
| 参考分子量 | MW(Observed):60kD |
| 预测分子量 | MW(Calculated):60kD |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia , Type 6. Alternative splicing results in multiple transcript variants. |
| 细胞定位 | Cell membrane |
| 功能 | Disease:Defects in SLC1A3 are the cause of episodic ataxia type 6 (EA6) [MIM:612656]. EA6 is characterized by episodic ataxia , seizures , migraine and alternating hemiplegia. ,Function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. ,PTM:Glycosylated. ,similarity:Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane |
| 组织表达 | Brain, Spinal cord, Retina, Glioma, Astrocytoma, Neuroblastoma |
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