货号：BSCY4006
Alpha 1 collagen type I;Alpha 1 type I collagen;Alpha 1 type I procollagen;Alpha 1;I;collagen;Alpha 1;I;procollagen;Alpha-1 type I collagen;CO1A1_HUMAN;COL1A1;Collagen alpha 1;I;chain;Collagen alpha-1;I;chain;Collagen I alpha 1 polypeptide;Collagen of ski
| 别名 | Alpha 1 collagen type I;Alpha 1 type I collagen;Alpha 1 type I procollagen;Alpha 1;I;collagen;Alpha 1;I;procollagen;Alpha-1 type I collagen;CO1A1_HUMAN;COL1A1;Collagen alpha 1;I;chain;Collagen alpha-1;I;chain;Collagen I alpha 1 polypeptide;Collagen of ski |
| 基因名称 | Collagen I |
| 蛋白名称 | Collagen I α1 (Cleaved-Ala1218) |
| 推荐应用 | |
| 反应物种 | Human,Mouse,Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| 特异性 | Endogenous |
| 稀释度 | WB 1:3000~1:10000;IHC-P 1:500-2000;IF-P 1:100-400 |
| 预测分子量 | 139 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. |
| 细胞定位 | Secreted, extracellular matrix, extracellular space. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Secreted, extracellular matrix, extracellular space. |
| 组织表达 | Skin, Bone, Tendon, Breast carcinoma, Osteosarcoma, Fibrosarcoma, Lung cancer |
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