| 别名 | MER; RP38; c-mer; MERTK; MERK; STK kinase; |
| 基因名称 | MERTK |
| 蛋白名称 | MERTK |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q12866 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:1000~1:2000;IHC 1:100-300 |
| 预测分子量 | 188kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. |
| 细胞定位 | Membrane |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane |
| 组织表达 | Retina, Spleen, Liver, Macrophages, Melanoma, Lymphoma, Renal cell carcinoma |
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