| 别名 | TPBG; 5T4; 5T4-AG; 5T4AG; 5T4 oncofetal antigen; M6P1; Trophoblast glycoprotein; |
| 基因名称 | 5T4 |
| 蛋白名称 | 5T4 |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q13641 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:1000;IHC 1:100-300 |
| 预测分子量 | 80kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | 5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60. |
| 细胞定位 | Membrane |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane |
| 组织表达 | Placenta, Kidney, Renal cell carcinoma, Lung cancer, Colorectal carcinoma, Ovarian carcinoma, Gastric carcinoma |
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