| 别名 | VN, S-protein, Serum-spreading factor, V75, VTN |
| 基因名称 | VTN |
| 蛋白名称 | Vitronectin |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P04004 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:300 |
| 预测分子量 | 75kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading , inhibits the membrane-damaging effect of the terminal cytolytic complement pathway , and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped , two chain form held together by a disulfide bond. |
| 细胞定位 | Secreted, Extracellular matrix |
| 功能 | Domain:The SMB domain mediates interaction with SERPINE1/PAI1. The heparin-binding domain mediates interaction with insulin. ,Function:Somatomedin-B is a growth hormone-dependent serum factor with protease-inhibiting activity. ,Function:Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway. ,PTM:It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability , thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. ,PTM:N- and O-glycosylated. ,PTM:Phosphorylation on Thr-69 and Thr-76 favors cell adhesion and spreading. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Secreted, Extracellular matrix |
| 组织表达 | Plasma, Liver, Kidney, Hepatocellular carcinoma, Renal cell carcinoma, Lung adenocarcinoma, Melanoma |
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