货号：BSCY30292
CD63, MLA1, TSPAN30, CD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, Lysosome integral membrane protein 1, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, Tetraspanin-30, LAMP-3, Limp1, Tspan-30
| 别名 | CD63, MLA1, TSPAN30, CD63 antigen, Granulophysin, Lysosomal-associated membrane protein 3, Lysosome integral membrane protein 1, Melanoma-associated antigen ME491, OMA81H, Ocular melanoma-associated antigen, Tetraspanin-30, LAMP-3, Limp1, Tspan-30 |
| 基因名称 | CD63 MLA1 TSPAN30 |
| 蛋白名称 | CD63 antigen (Granulophysin) (Lysosomal-associated membrane protein 3) (LAMP-3) (Lysosome integral membrane protein 1) (Limp1) (Melanoma-associated antigen ME491) (OMA81H) (Ocular melanoma-associated antigen) (Tetraspanin-30) (Tspan-30) (CD antigen CD63) |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P08962 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:300 |
| 预测分子量 | 26kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene is a member of the transmembrane 4 superfamily , also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development , activation , growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. |
| 细胞定位 | Membrane, Lysosome |
| 功能 | Function:This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation. ,miscellaneous:Lack of expression of CD63 in platelets has been observed in a patient with Hermansky-Pudlak syndrome (HPS) . Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous , rare , autosomal recessive disorder characterized by oculocutaneous albinism , bleeding due to platelet storage pool deficiency , and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes , platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis , a common cause of premature death in individuals with HPS. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane, Lysosome |
| 组织表达 | Ubiquitous expression |
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