| 别名 | Somatostatin receptor type 2, SS-2-R, SS2-R, SS2R, SST2, SRIF-1, SSTR2 |
| 基因名称 | SSTR2 |
| 蛋白名称 | somatostatin receptor 2 |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | P30874 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:300 |
| 预测分子量 | 41kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. |
| 细胞定位 | Membrane |
| 功能 | Function:Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells , this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. ,similarity:Belongs to the G-protein coupled receptor 1 family. ,subunit:The C-terminus interacts with SHANK1 PDZ domain. ,tissue specificity:Cerebrum and kidney. In lesser amounts in jejunum , colon and liver. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane |
| 组织表达 | Pancreas, Brain, Stomach, Pancreatic neuroendocrine tumor, Gastrinoma, Insulinoma, Small cell lung cancer |
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