| 别名 | FKHR, FOXO1A, FOXO1, Forkhead box protein O1, Forkhead box protein O1A, Forkhead in rhabdomyosarcoma |
| 基因名称 | FOXO1 |
| 蛋白名称 | Forkhead box protein O1 |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Swissprot No. | Q12778 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:300 |
| 预测分子量 | 70kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however , it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. |
| 细胞定位 | Nucleus, Cytoplasm |
| 功能 | Disease:Chromosomal aberrations involving FOXO1 are a cause of rhabdomyosarcoma 2 (RMS2) [MIM:268220]; also known as alveolar rhabdomyosarcoma. Translocation (2;13) (q35;q14) with PAX3; translocation t (1;13) (p36;q14) with PAX7. The resulting protein is a transcriptional activator. ,Function:Transcription factor. ,PTM:Phosphorylated by AKT1; insulin-induced (By similarity) . IGF1 rapidly induces phosphorylation of Ser-256 , Thr-24 , and Ser-319. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24 , and Ser-319 , permitting phosphorylation of Ser-322 and Ser-325 , probably by CK1 , leading to nuclear exclusion and loss of function. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Phosphorylated upon DNA damage , probably by ATM or ATR. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus, Cytoplasm |
| 组织表达 | Liver, Adipose tissue, Muscle, Breast carcinoma, Lung cancer, Colorectal carcinoma, Prostate carcinoma |
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