| 别名 | HDLCQ11; LIPD; Lipoprotein lipase; LPL; LPL protein; |
| 基因名称 | Lipoprotein lipase |
| 蛋白名称 | Lipoprotein lipase |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 4023; |
| Human Swissprot No. | P06858 |
| Mouse Gene ID | 16956 |
| Mouse Swissprot No. | P11152 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:1000~1:5000 |
| 参考分子量 | MW(Observed): 53 kDa |
| 预测分子量 | MW(Calculated): 53 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium. |
| 细胞定位 | Cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted . Secreted , extracellular space , extracellular matrix . Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently , it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232) . Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL) . Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity) . . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted . Secreted , extracellular space , extracellular matrix . Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently , it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232) . Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL) . Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity) . . |
| 组织表达 | Adipose tissue, Heart, Skeletal muscle, Adipocytic tumor, Cardiac sarcoma |
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