| 别名 | FMR1; Fmr1 gene; FMRP; Fragile X mental retardation 1; Fragile X mental retardation 1 protein; FRAXA;POF; POF1; Protein FMR-1; Protein FMR1; |
| 基因名称 | FMRP |
| 蛋白名称 | FMRP |
| 推荐应用 | |
| 反应物种 | Human Mouse Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 2332; |
| Human Swissprot No. | Q06787 |
| Mouse Gene ID | 14265 |
| Mouse Swissprot No. | P35922 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed): 70-80 kDa |
| 预测分子量 | MW(Calculated): 71 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. |
| 细胞定位 | Nucleus . Nucleus , nucleolus . Chromosome , centromere . Chromosome . Cytoplasm . Cytoplasm , perinuclear region . Cytoplasm , Cytoplasmic ribonucleoprotein granule . Perikaryon . Cell projection , neuron projection . Cell projection , axon . Cell projection , dendrite . Cell projection , dendritic spine . Cell junction , synapse , synaptosome . Cell projection , growth cone . Cell projection , filopodium tip . Cell junction , synapse . Cell junction , synapse , postsynaptic cell membrane . Cell junction , synapse , presynaptic cell membrane . Cell membrane . Cytoplasm , Stress granule . Colocalizes with H2AX/H2A.x in pericentromeric heterochromatin in response to DNA damaging agents (By similarity) . Localizes on meiotic pachytene-stage chromosomes (By similarity) . Forms nuclear foci representing sites of ongoing DNA replication in response to DNA damaging agents (By similarity) . Shuttles between nucleus and cytoplasm in a XPO1/CRM1-dependent manner (PubMed:10196376) . Localizes to cytoplasmic ribonucleoprotein granules , also referred to as messenger ribonucleoprotein particles or mRNPs , along dendrites and dendritic spines (PubMed:9659908 , PubMed:14532325) . FMR1-containing cytoplasmic granules colocalize to F-actin-rich structures , including filopodium , spines and growth cone during the development of hippocampal neurons (By similarity) . FMR1-containing cytoplasmic granules are transported out of the soma along axon and dendrite to synaptic contacts in a microtubule- and kinesin-dependent manner (PubMed:12417734 , PubMed:15380484) . Colocalizes with CACNA1B in the cytoplasm and at the cell membrane of neurons (By similarity) . Colocalizes with CYFIP1 , CYFIP2 , NXF2 and ribosomes in the perinuclear region (By similarity) . Colocalizes with CYFIP1 and EIF4E in dendrites and probably at synapses (By similarity) . Colocalizes with FXR1 , kinesin , 60S acidic ribosomal protein RPLP0 and SMN in cytoplasmic granules in the soma and neurite cell processes (PubMed:12417734 , PubMed:18093976 , PubMed:16636078) . Colocalizes with FXR1 and FXR2 in discrete granules , called fragile X granules (FXGs) , along axon and presynaptic compartments (By similarity) . Colocalizes with TDRD3 in cytoplasmic stress granules (SGs) in response to various cellular stress (PubMed:18632687 , PubMed:18664458 , PubMed:16636078) . .; [Isoform 6]: Cytoplasm . Cytoplasm , perinuclear region .; [Isoform 9]: Cytoplasm .; [Isoform 10]: Nucleus . Nucleus , Cajal body . Colocalizes with Colin and SMN in Cajal bodies (PubMed:24204304) .; [Isoform 11]: Nucleus . Nucleus , Cajal body . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Nucleus . Nucleus , nucleolus . Chromosome , centromere . Chromosome . Cytoplasm . Cytoplasm , perinuclear region . Cytoplasm , Cytoplasmic ribonucleoprotein granule . Perikaryon . Cell projection , neuron projection . Cell projection , axon . Cell projection , dendrite . Cell projection , dendritic spine . Cell junction , synapse , synaptosome . Cell projection , growth cone . Cell projection , filopodium tip . Cell junction , synapse . Cell junction , synapse , postsynaptic cell membrane . Cell junction , synapse , presynaptic cell membrane . Cell membrane . Cytoplasm , Stress granule . Colocalizes with H2AX/H2A.x in pericentromeric heterochromatin in response to DNA damaging agents (By similarity) . Localizes on meiotic pachytene-stage chromosomes (By similarity) . Forms nuclear foci representing sites of ongoing DNA replication in response to DNA damaging agents (By similarity) . Shuttles between nucleus and cytoplasm in a XPO1/CRM1-dependent manner (PubMed:10196376) . Localizes to cytoplasmic ribonucleoprotein granules , also referred to as messenger ribonucleoprotein particles or mRNPs , along dendrites and dendritic spines (PubMed:9659908 , PubMed:14532325) . FMR1-containing cytoplasmic granules colocalize to F-actin-rich structures , including filopodium , spines and growth cone during the development of hippocampal neurons (By similarity) . FMR1-containing cytoplasmic granules are transported out of the soma along axon and dendrite to synaptic contacts in a microtubule- and kinesin-dependent manner (PubMed:12417734 , PubMed:15380484) . Colocalizes with CACNA1B in the cytoplasm and at the cell membrane of neurons (By similarity) . Colocalizes with CYFIP1 , CYFIP2 , NXF2 and ribosomes in the perinuclear region (By similarity) . Colocalizes with CYFIP1 and EIF4E in dendrites and probably at synapses (By similarity) . Colocalizes with FXR1 , kinesin , 60S acidic ribosomal protein RPLP0 and SMN in cytoplasmic granules in the soma and neurite cell processes (PubMed:12417734 , PubMed:18093976 , PubMed:16636078) . Colocalizes with FXR1 and FXR2 in discrete granules , called fragile X granules (FXGs) , along axon and presynaptic compartments (By similarity) . Colocalizes with TDRD3 in cytoplasmic stress granules (SGs) in response to various cellular stress (PubMed:18632687 , PubMed:18664458 , PubMed:16636078) . .; [Isoform 6]: Cytoplasm . Cytoplasm , perinuclear region .; [Isoform 9]: Cytoplasm .; [Isoform 10]: Nucleus . Nucleus , Cajal body . Colocalizes with Colin and SMN in Cajal bodies (PubMed:24204304) .; [Isoform 11]: Nucleus . Nucleus , Cajal body . |
| 组织表达 | Brain, Testis, Ovary, Glioma, Testicular cancer, Ovarian cancer. |
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