| 别名 | CD156b; ADAM17; CSVP; TACE; |
| 基因名称 | ADAM17 |
| 蛋白名称 | ADAM17 |
| 推荐应用 | |
| 反应物种 | Mouse Rat(WB);Human Mouse Rat(IHC) |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 6868; |
| Human Swissprot No. | P78536 |
| Mouse Gene ID | 11491; |
| Mouse Swissprot No. | Q9Z0F8 |
| Rat Gene ID | 57027; |
| Rat Swissprot No. | Q9Z1K9; |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed): 100 kDa |
| 预测分子量 | MW(Calculated): 93 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | TACE is responsible for the shedding of EGFR ligands such as amphiregulin and TNF-α. Some tumors have hyperactivated EGFR due to upregulated TNF-α production and upregulated TACE, making TACE a potential target for drug development. TACE activates Notch in a ligand-independent manner and has been shown to play a role in the development of the Drosophila nervous system. |
| 细胞定位 | Membrane; Single-pass type I membrane protein. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织表达 | Ubiquitous expression |
周一至周日 8:00-18:00
