| 别名 | Ago 2; Argonaute 2; dAgo2; eIF2C 2; hAgo2; PPD; |
| 基因名称 | Argonaute 2 |
| 蛋白名称 | Argonaute 2 |
| 推荐应用 | |
| 反应物种 | Human(WB);Human Mouse Rat(IHC) |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 27161; |
| Human Swissprot No. | Q9UKV8 |
| Mouse Gene ID | 239528; |
| Mouse Swissprot No. | Q8CJG0 |
| Rat Gene ID | 59117; |
| Rat Swissprot No. | Q9QZ81; |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:500~1:2000 |
| 参考分子量 | MW(Observed): 97 kDa |
| 预测分子量 | MW(Calculated): 97 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). Can also upregulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and upregulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions. |
| 细胞定位 | Cytoplasm , P-body . Nucleus . Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm , P-body . Nucleus . Translational repression of mRNAs results in their recruitment to P-bodies. Translocation to the nucleus requires IMP8. |
| 组织表达 | Ubiquitous expression |
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