| 别名 | BMI1 ; Polycomb complex protein BMI 1; RING finger protein 51; RNF51; PCGF4; |
| 基因名称 | Bmi1 |
| 蛋白名称 | Bmi1 |
| 推荐应用 | |
| 反应物种 | Human Rat |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 648; |
| Human Swissprot No. | P35226 |
| Mouse Swissprot No. | P25916 |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:2000 |
| 参考分子量 | MW(Observed): 40 kDa |
| 预测分子量 | MW(Calculated): 37 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | The polycomb group (PcG) of proteins contributes to the maintenance of cell identity, stem cell self-renewal, cell cycle regulation, and oncogenesis by maintaining the silenced state of genes that promote cell lineage specification, cell death, and cell-cycle arrest. PcG proteins exist in two complexes that cooperate to maintain long-term gene silencing through epigenetic chromatin modifications. The first complex, EED-EZH2, is recruited to genes by DNA-binding transcription factors and methylates histone H3 on Lys27. |
| 细胞定位 | Cytoplasm, Nucleus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm, Nucleus. |
| 组织表达 | Ubiquitous expression |
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