| 别名 | C-Raf; CRAF; Protein kinase raf 1; RAF1; Raf proto-oncogene serine/threonine-protein kinase; kinase Raf1; |
| 基因名称 | Phospho-Raf1 (S43) |
| 蛋白名称 | Phospho-Raf1 (S43) |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 5894 |
| Human Swissprot No. | P04049 |
| Mouse Gene ID | 110157 |
| Mouse Swissprot No. | Q99N57 |
| Rat Gene ID | 24703 |
| Rat Swissprot No. | P11345; |
| 特异性 | Endogenous |
| 稀释度 | WB 1:500~1:1000 |
| 参考分子量 | MW(Observed): 73 kDa |
| 预测分子量 | MW(Calculated): 73 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. |
| 细胞定位 | Cell membrane, Cytoplasm, Mitochondrion, Nucleus. |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Phospho |
| 细胞定位 | Cell membrane, Cytoplasm, Mitochondrion, Nucleus. |
| 组织表达 | Ubiquitous expression |
周一至周日 8:00-18:00
