| 别名 | eIF-2A protein kinase 2; Protein kinase RNA-activated; PKR; p68 kinase; P1/eIF-2A protein kinase; |
| 基因名称 | PKR |
| 蛋白名称 | PKR |
| 推荐应用 | |
| 反应物种 | Human |
| 存储缓冲液 | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Human Gene Link | 5610; |
| Human Swissprot No. | P19525 |
| Mouse Gene ID | 19106 |
| Mouse Swissprot No. | Q03963 |
| Rat Gene ID | 54287 |
| Rat Swissprot No. | Q63184 |
| 特异性 | Endogenous |
| 稀释度 | IHC 1:100-1:500;WB 1:10000~1:20000 |
| 参考分子量 | MW(Observed): 68 kDa |
| 预测分子量 | MW(Calculated): 62 kDa |
| 运输及保存条件 | -15°C to -25°C/1 year(Do not lower than -25°C) |
| 宿主 | Rabbit |
| 同种型 | IgG,Kappa |
| 背景介绍 | PKR a protein kinase of the PEK family. Upon binding double-stranded RNA, it becomes autophosphorylated and activated. Phosphorylates and inhibits the alpha subunit of eIF2 alpha, which leads to an inhibition of the initiation of protein synthesis. |
| 细胞定位 | Cytoplasm . Nucleus . Cytoplasm , perinuclear region . Nuclear localization is elevated in acute leukemia , myelodysplastic syndrome (MDS) , melanoma , breast , colon , prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients. . |
| 纯化 | Protein A |
| Clonality | Monoclonal |
| 修饰类型 | Unmodified |
| 细胞定位 | Cytoplasm . Nucleus . Cytoplasm , perinuclear region . Nuclear localization is elevated in acute leukemia , myelodysplastic syndrome (MDS) , melanoma , breast , colon , prostate and lung cancer patient samples or cell lines as well as neurocytes from advanced Creutzfeldt-Jakob disease patients. . |
| 组织表达 | Spleen, Lymph node, Bone marrow, Lymphoma, Leukemia, Melanoma, Breast carcinoma |
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